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KMID : 0368820050440010125
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Journal of the Korean Neuropsychiatr Association
2005 Volume.44 No. 1 p.125 ~ p.128
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Dilated Cardiomyopathy Associated with Clozapine.
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Roh Sung-Won
Ahn Dong-Hyun
Kim Yang-Suk
Lee Bang-Hun
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Abstract
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Clozapine is an atypical antipsychotic agent that is more effective than the typical neuroleptics in the treatment of refractory schizophrenia. However, clozapine is also a drug associated with potentially serious adverse effects, such as cardiac complications as well as agranulocytosis. Clozapine-related agranulocytosis has been reported in Korea, whereas clozapine-related cardiac complications have not. We report a 31-year-old male schizophrenia treated with clozapine who developed a dilated cardiomyopathy. We also reviewed literatures on dilated cardiomyopathy associated with clozapine treatment. This report is an attempt to raise the awareness of clozapine-related cardiac complications.
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KEYWORD
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Clozapine, Dilated cardiomyopathy
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